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核子工程與科學研究所

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Fang-Hsin Chen

陳芳馨 Fang-Hsin Chen Associate Professor

Address：LTM Building Room 509
E-mail：fanghsin@mx.nthu.edu.tw
Telephone No.：03-5715131 ext.42371
Laboratory：Radiation Biology Lab
Discipline

Radiation Biology

Specialty
  • Molecular radiobiology
  • Tumor microenvironment (tumor-associated macrophage, mechanism of angiogenesis)
  • Overcome radio-resistance by small RNA
  • Metabolomic, lipidomic and radiomic features extracted from tumor and normal tissues responses induced by RT
  • Dynamic 13C-pyruvate metabolism after radiotherapy detected by DNP-MRI
Academic Degrees

  1. Taiwan, National Tsing Hua University, Biomedical Engineering and Environmental Sciences Ph.D., 2002/09~2009/06
Journal Articles

  1. Chun-Chieh Chan, Fang-Hsin Chen, Kuang-Lung Hsueh and Ya-Yun Hsiao. The Effect of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for Cells Irradiated with Grenz Rays. Cancers; 2022, 14, 1262 

  2. Ya-Yun Hsiao, Fang-Hsin Chen, Chun-Chieh Chan and Ching-Chih Tsai. Monte Carlo Simulation of Double-strand Break Induction and Conversion after Ultrasoft X-Rays Irradiation. International Journal of Molecular Sciences; 2021, 22, 11713. 

  3. Min Gao, Hsien-Hsin Chen, Fang-Hsin Chen, Ji-Hong Hong, Ing-Tsung Hsiao, Tzu-Chen Yen, Jingfang Mao, Jiade J. Lu, Weidong Wang, Nicola D’Ascenzo, Qingguo Xie. First Results from All-digital PET Dual Heads for In-beam Beam-on Proton Therapy Monitoring. IEEE Transactions on Radiation and Plasma Medical Sciences; 2021, 5(6), 775

  4. Ching-Fang Yu, Chun-Hsiang Chang, Ji-Hong Hong, Chi-Shiun Chiang* and Fang-Hsin Chen*. Local interleukin-12 treatment enhances the efficacy of radiation therapy by overcome radiation-induced immune suppression. International Journal of Molecular Sciences; 2021, 22, 10053 

  5. Ying-Chieh Lai, Ching-Yi Hsieh, Kuan-Ying Lu, Cheng-Hsuan Sung, Hung-Yao Ho, Mei-Ling Cheng, Albert P. Chen, Shu-Hang Ng, Fang-Hsin Chen* and Gigin Lin*.  Monitor early glycolytic flux alterations following radiotherapy in cancer and immune cells: Hyperpolarized carbon-13 magnetic resonance imaging study. Metabolites; 2021, 11, 518 (Co-corresponding author)

  6. Jeffrey Yung-Chuan Chao, Hsin-Chuan Chang, Jeng-Kai Jiang, Chih-Yung Yang, Fang-Hsin Chen, Yo-Liang Lai, Wen-Jen Lin, Chia-Yang Li, Shu-Chi Wang, Muh-Hwa Yang, Yu-Feng Lin, Wei-Chung Cheng. Using bioinformatics approaches to investigate driver genes and identify BCL7A as a prognostic gene in colorectal cancer. Computational and Structural Biotechnology Journal; 2021, 19, 3922 

  7. Chun-Chieh Chan, Fang-Hsin Chen and Ya-Yun Hsiao. Impact of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for a 62-MeV Therapeutic Proton Beam. Cancers; 2021, 13, 2997 

  8. Lin, Wen Jen; Shen, Pei-Chun; Liu, Hsiu-Cheng; Cho, Yi-Chun; Hsu, Min-Kung; Lin, I-Chen; Chen, Fang-Hsin; Yang, Juan‐Cheng; Ma, Wen-Lung; Cheng, Wei-Chung. LipidSig: a web-based tool for lipidomic data analysis. Nucleic Acids Research; 2021, 49(W1), W336 

  9. Yi-Hsiu Chung, Cheng-Kun Tsai, Ching-Fang Yu, Wan-Ling Wang, Chung-Lin Yang, Ji-Hong Hong, Tzu-Chen Yen, Fang-Hsin Chen*, Gigin Lin* (Co-corresponding author) Radiation-induced metabolic shifts in the hepatic parenchyma: findings from 18F-FDG PET imaging and tissue NMR metabolomics in a mouse model for hepatocellular carcinoma, Molecules; 2021, 26(9), 2573 

  10. Kai-Wen Hsu†, Shu-Hsuan Liu†, Yo-Liang Lai, Fang-Hsin Chen, Li-Jie Lin, Pei-Hwa Peng, Chia-Yang Li, Shu-Chi Wang, Ji-Lin Chen, Heng-Hsiung Wu, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng. Systematic identification of clinically relevant miRNAs for potential miRNA-based therapy in lung adenocarcinoma, Molecular Therapy-Nucleic Acids; 2021, 25, 1 

  11. Yumei Qi, Yo‐Liang Lai, Pei‐Chun Shen, Fang‐Hsin Chen, Li‐Jie Lin, Heng‐Hsiung Wu, Pei‐Hua Peng, Kai‐Wen Hsu & Wei‐Chung Cheng. Identification and validation of a miRNA-based prognostic signature for cervical cancer through an integrated bioinformatics approach. Scientific Reports; 2020, 10, article 22270 

  12. Sheng-Yung Fu, Fang-Hsin Chen, Chun-Chieh Wang, Ching-Fang Yu, Chi-Shiun Chiang, Ji-Hong Hong. Role of Myeloid-derived Suppressor Cells in High-dose Irradiated TRAMP-C1 tumors: A Therapeutic Target and an Index for Assessing Tumor Microenvironment. International Journal of Radiation Oncology Biology Physics; 2020, 109 (5), 1547-1558 

  13. Lu-Kai Wang, Tsai-Jung Wu, Ji-Hong Hong, Fang-Hsin Chen, John Yu and Chun-Chieh Wang. Radiation Induces Pulmonary Fibrosis by Promoting the Fibrogenic Differentiation of Alveolar Stem Cells. Stem Cells International; 2020, Article 6312053, 1~12 

  14. Chun-Chia Cheng, Po-Jui Hsu, Zong-Lin Sie, Fang-Hsin Chen*. Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-like Tumorspheres. Journal of Visualized Experiments; 2020, 161, e61077 

  15. Lan-Hui Li, Tzu-Ling Chen, Hsiao-Wen Chi3, Chung-Hua Hsu, Chien-Chun Wang, Tzu-Ting Tai, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Chernikov, Wen-Chiuan Tsai and Kuo-Feng Hua.  Critical Role for the NLRP3 Inflammasome in Mediating IL-1β Production in Shigella sonnei-Infected Macrophages. Frontiers in Immunology; 2020, 11, article 1115 

  16. Sheng-Yung Fu*, Chun-Chieh Wang*, Fang-Hsin Chen, Ching-Fang Yu, Ji-Hong Hong, Chi-Shiun Chiang. Sunitinib treatment-elicited Distinct Tumor Microenvironment Dramatically Compensated the Reduction of Myeloid-derived Suppressor Cells.  In Vivo; 2020, 34, 1141-1152 

  17. Fang-Hsin Chen*, Ching-Fang Yu, Chung-Lin Yang, Yu-Chun Lin, Gigin Lin, Chun-Chieh Wang, Huang-Ping Yu, Jui Fang, Ning-Fang Chang & Ji-Hong Hong. Multimodal imaging reveals transient liver metabolic disturbance and sinusoidal circulation obstruction after a single administration of ketamine/xylazine mixture. Scientific Reports; 2020, 10, article 3657 

  18. Chih-Yu Hsieh, Lan-Hui Li, Yulin Lam, Zhanxiong Fang, Chin Heng Gan, Yerra Koteswara Rao, Hsiao-Wen Chiu, Wei-Ting Wong, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Chernikov, May-Lan Liu, Chung-Hua Hsu, Kuo-Feng Hua. Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome. Cells; 2020, 9, 279 

  19. Shu-Hsuan Liu, Pei-Chun Shen, Chen-Yang Chen, An-Ni Hsu, Yi-Chun Cho, Yo-Liang Lai, Fang-Hsin Chen, Chia-Yang Li, Shu-Chi Wang, Ming Chen, I-Fang Chung and Wei-Chung Cheng. DriverDBv3: A multi-omics database for cancer driver gene research. Nucleic Acids Research; 2020, 48, D863-D870 

  20. Bo-Rong Lin, Chiung-Chi Wang, Chien-Hsu Chen, Srinivasu Kunuku, Tung-Yuan Hsiao, Hung-Kai Yu, Tzung-Yuang Chen, Yu-Jen Chang, Li-Chuan Liao, Chun-Hsiang Chang, Fang-Hsin Chen, Huan Niu and Chien-Ping Lee. Secondary Ion Mass Spectroscopy to Verify the Implantation of Magnetic Ions in Nanodiamonds. Journal of Applied Physics; 2019, 126, 175301 

  21. Wei-Ren Luo, Fang-Hsin Chen, Ren-Jing Huang, Yu-Pin Chen, and Ya-Yun Hsiao. Effects of Indirect Actions and Oxygen on Relative Biological Effectiveness: Estimate of DSB Inductions and Conversions Induced by Therapeutic Proton Beams. International Journal of Radiation Biology; 2019, 96(2), 187-192 

  22. Bo-Rong Lin, Chien-Hsu Chen, Chun-Hsiang Chang, Srinivasu Kunuku, Tzung-Yuang Chen, Tung-Yuan Hsiao, Hung-Kai Yu,Yu-Jen Chang, Li-Chuan Liao, Fang-Hsin Chen, Huan Niu and Chien-Ping Lee. Iron embedded magnetic nanodiamonds for in vivo MRI contrast enhancement. Journal of Physics D: Applied Physics; 2019, 52, 505402 (6pp) 

  23. Lan-Hui Li, Jia-Sing Lin, Hsiao-Wen Chiu, Wen-Yu Lin, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Cherniko, May-Lan Li, Jen-Che Chang, Chung-Hua Hsu, Ann Chen, Shuk-Man Ka, Hong-Wei Gao and Kuo-Feng Hua. Mechanistic Insight into the Activation of the NLRP3 Inflammasome by Neisseria gonorrhoeae in Macrophages. Frontiers in Immunology; 2019, 10, article 1815 

  24. Chiu-Min Lin, Ching-Fang Yu, Hsueh-Ya Huang, Fang-Hsin Chen, Ji-Hong Hong and Chi-Shiun Chiang. Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated with Therapeutic Resistance for Brain Tumor. Frontiers in Oncology; 2019, 9, article 307 

  25. Yi-Hsiu Chung, Ching-Fang Yu, Shao-Chieh Chiu, Han Chiu, Shin-Ting Hsu, Ching-Rong Wu, Chung-Lin Yang, Ji-Hong Hong, Tzu-Chen Yen*, Fang-Hsin Chen*, Diffusion-weighted MRI and 18F-FDG PET correlation with immunity in early radiotherapy response in BNL hepatocellular carcinoma mouse model: timeline validation. European Journal of Nuclear Medicine and Molecular Imaging; 2019, 46(8):1733-1744

  26. Hsiao-Wen Chiu, Lan-Hui Li, Chih-Yu Hsieh, Yerra Koteswara Rao, Fang-Hsin Chen, Ann Chen, Shuk-Man Ka, Kuo-Feng Hua, Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome. Scientific Reports; 2019, 9, article 5603 

  27. I-Chun Cho, Huan Niu, Yi-Cheng Liu, Tsair-Fwu Lee, Fang-Hsin Chen*, Application of a vertical charged-particle irradiation platform in glioblastoma multiforme cancer stem cell research. Nuclear Instrument and Methods in Physics Research B: Beam Interactions with Materials and Atoms, 2019, 441,102-107 

  28. Nicola D’Ascenzo, Min Gao, Emanuele Antonecchia, Paolo Gnudi, Hsien-Hsin Chen, Fang-Hsin Chen, Ji-Hong Hong, Ing-Tsung Hsiao, Tzu-Chen Yen, Weidong Wang, Daoming Xi, Bo Zhang and Qingguo Xie.New, Digital Plug and Imaging Sensor for a Proton Therapy Monitoring System Based on Positron Emission Tomography, Sensors; 2018, 18, 3006 

  29. I-Chun Cho*, Fang-Hsin Chen*, Tsi-Chian Chao, Chuan-Jong Tung, A Monte Carlo study of bone-tissue interface microdosimeters, Applied Radiation and Isotopes; 2018, 140: 193-200 (Co-first author)

  30. Wei-Hsiang Kung, Chi-Lung Lee, Chi-Dung Yang, Ching-Fang Yu, Men-Yee Chiew, Fang-Hsin Chen*, and Hsien-Da Huang*, Integrated microRNA and mRNA Expression Profile Analysis of Tumor Associated Macrophages after Exposure to Single-Dose Irradiation, Computational Biology and Chemistry; 2018, 74: 368-378 (Co-corresponding author)

  31. Ching-Fang Yu, Fang-Hsin Chen, Meng-Hsuan Lu, Ji-Hong Hong, and Chi-Shiun Chiang, Dual roles of tumor cells-derived matrix metalloproteinase 2 on brain tumor growth and invasion, British Journal of Cancer; 2017, 117(12): 1828-1836 

  32. Wei-Hsiang Kung, Ching-Fang Yu, Andy Chi-Lung Lee, Chi-Dung Yang, Yu-Chen Liu, Fang-Hsin Chen*, Hsien-Da Huang*, Gene expression profiling of tumor-associated macrophages after exposure to single-dose irradiation, Computational Biology and Chemistry; 2017, 69: 138–146 (Co-corresponding author)

  33. Yu-Chun Lin, Gigin Lin, Ji-Hong Hong, Yi-Ping Lin, Fang-Hsin Chen, Shu-Hang Ng, and Chun-Chieh Wang, Diffusion Radiomics Analysis of Intratumoral Heterogeneity in a Murine Prostate Cancer Model Following Radiotherapy: Pixelwise Correlation with Histology, Journal of Magnetic Resonance Imaging; 2017, 46 (2):483-489 

  34. Cheng-He Li*, Fang-Hsin Chen*, Dawid Schellingerhout, Yu-Shi Lin, Ji-Hong Hong, Ho-Ling Liu. Flow versus Permeability Weighting in Estimating the Forward Volumetric Transfer Constant (Ktrans) Obtained by DCE-MRI with Contrast Agents of Differing Molecular Sizes, Magnetic Resonance Imaging; 2017, 36: 105–111(Co-first author)

  35. Fang-Hsin Chen*, Chun-Chieh Wang, Ho-Ling Liu, Sheng Yung Fu, Ching-Fang Yu, Chen Chang, Chi-Shiun Chiang and Ji-Hong Hong, Decline of Tumor Vascular Function as Assessed by DCE-MRI is Associated with Poor Responses to Radiotherapy and Chemotherapy, International Journal of Radiation Oncology Biology Physics; 2016, 95:1495-1503 

  36. Ju-Ying Tsai, Fang-Hsin Chen, Tsung-Yu Hsieh and Ya-Yun Hsiao, Effects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB induction and conversion induced by gamma rays and helium ions, Journal of Radiation Research; 2015 Jul;56(4):691-9 

  37. Ching-Fang Yu, Chi-Min Lin, Shu-Chi Wang, Fang-Hsin Chen, Ji-Hong Hong, Chien-Sheng Tsai, Ying-Chieh Yang, and Chi-Shiun Chiang, Effects of pre-irradiation and SDF-1 suppression on the progression of murine astrocytoma cells grown in different stromal beds, International Journal of Radiation Biology; 2014 Dec;90(12):1162-8 

  38. Fang-Hsin Chen*, Ji-Hong Hong, Sheng-Yung Fu, Chun-Chieh Wang and Chi-Shiun Chiang, Combination of Vessel-targeting Agents with Fractionated Radiotherapy: The Role of SDF-1/CXCR4 Pathway, International Journal of Radiation Oncology Biology Physics; 2013, 86(4), 777–784 

  39. Chi-Shiun Chiang, Sheng Yung Fu, Shu-Chi Wang, Ching-Fang Yu, Fang Hsin Chen, Chi-Min Lin and Ji-Hong Hong, Irradiation promotes an M2 macrophage phenotype in tumor hypoxia, Frontiers in Oncology; 2012, 2, article 89 

  40. Kun-Ju Lin, Chun-Chung Wu, Yi-Hsin Pan, Fang-Hsing Chen, Sheng-Yung Fu, Chi-Shiun Chiang, Ji-Hong Hong, Jem-Mau Lo, In vivo imaging of radiation-induced tissue apoptosis by 99mTc(I) his6-annexin A5, Annals of Nuclear Medicine; 2012, 26, 272-280 

  41. Fang-Hsin Chen *, Chi-Shiun Chiang, Chun-Chieh Wang, Sheng-Yung Fu, Chien-Sheng Tsai, Shih-Ming Jung, Chih-Jen Weng, Chung-Chi Lee and Ji-Hong Hong, Vasculatures in tumors growing from preirradiated tissues: formed by vasculogenesis and resistant to radiation and anti-angiogenic therapy, International Journal of Radiation Oncology Biology Physics; 2011, 80(5), 1512–21 

  42. Fang-Hsin Chen*, Chi-Shiun Chiang, Chun-Chieh Wang, Chien-Sheng Tsai, Shih-Ming Jung, Chung-Chi Lee, William H. McBride, and Ji-Hong Hong, Radiotherapy Decreases Vascular Density and Causes Hypoxia with Macrophage Aggregation in TRAMP-C1 Prostate Tumors, Clinical Cancer Research; 2009, 15(5), 1721-1729 

  43. Chi-Shiun Chiang, Fang-Hsin Chen, Ji-Hong Hong, Pei-Shin Jiang, Hsiang-Ling Huang, Chun-Chieh Wang and William H. McBride, Functional Phenotype of Macrophages Depends on Assay Procedures, International Immunology; 2007; 20(2), 215–222 

  44. Chien-Sheng Tsai, Fand-Hsin Chen, Chun-Chieh Wang, Hsiang-Ling Huang, Shih-Ming Jung, Chi-Jung Wu, Chung-Chi Lee, William H. McBride, Chi-Shiun Chiang, and Ji-Hong Hong, Macrophages from Irradiated Tumors Express Higher Levels of iNOS, Arginase-I and COX-2, and Promote Tumor Growth, International Journal of Radiation Oncology Biology Physics; 2007, 68(2), 499–507 

  45. Chi-Shiun Chiang, Wei-Chung Liu, Shih-Ming Jung, Fang-Hsin Chen, Chi-Rong Wu, William H. McBride, Chung-Chi Lee, and Ji-Hong Hong, Compartmental Responses after Thoracic Irradiation of Mice: Strain Differences, International Journal of Radiation Oncology Biology Physic; 2005, 62(3), 862–871 

  46. Ji-Hong Hong, Shih-Ming Jung, Thomas Chang Yao Tsao, Chi-Jung Wu, Chin-Yi Lee, Fang-Hsin Chen, Chung-Hsen Hsu, William H. McBride and Chi-Shiun Chiang, Bronchoalveolar lavage and interstitial cells have different roles in radiation-induced lung injury, International Journal of Radiation Oncology Biology Physics; 2003, 79(3), 158-167 
     
 
Experience

  1.  Associate Professor, Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taiwan, 08/2019~07/2022

  2. Associate Research Fellow (joint appointment) and Director, Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University, Taiwan, 08/2020~07/2022

  3. Research Fellow (joint appointment), Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou branch, Taiwan, 01/2016 ~07/2022

  4. Research Fellow (joint appointment), Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University, Taiwan, 01/2014 to 08/2019.

  5. Assistant Professor, Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taiwan, 08/2013 to 08/2019

  6. Postdoctoral Fellow, Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan, 08/2009 to 07/2013
     
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